Published: May 1, 2019
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By: Chamey Suchors, Tarleton State University
Hashtags: #biochemistry #cancerresearch #Cellculture #Presentation #Research #undergradate
This is the research presentation that Josh Moore and I presented in front of the chemistry faculty for the Spring 2019 semester.
In Vitro Studies on Plant-Based Drug Delivery Systems
Drug delivery systems are vitally important to the efficient delivery of chemotherapeutic agents due to their regulation of both the location of and the rate at which the drug is released. This helps to minimize unnecessary interaction with non-pathological sites, which otherwise could result in negative effects. Currently available drug delivery systems display high levels of cytotoxicity. Therefore, it is imperative to develop delivery systems that are both highly effective and non-toxic to the organism. Delivery systems derived from natural biological polysaccharides are far more stable, hydrophilic, biodegradable, easily and cheaply obtained, and are significantly less toxic. Insofar, this research has developed four such non-toxic plant-based polysaccharide drug delivery systems. The four delivery systems are currently being employed in cell culture experiments to determine their cytotoxicity in pancreatic carcinoma cell lines. The results from this in vitro experiment thus far have indicated that the four delivery systems possess a very low level of cytotoxicity, especially when compared to that of a current delivery system, polyethyleneimine (PEI). The numerous accolades of the plant-based drug delivery systems should allow it to effectively deliver the chemotherapeutic agents without the harmful effects of current delivery systems. The current research aims to graft the chemotherapeutic agent to a plant-based delivery system to definitively prove that the agent is still effective once attached to the plant-based delivery system but does not display the cytotoxicity of currently available delivery systems.